One of the major differences between DNA and RNA is that

Explanation

DNA (Deoxyribonucleic Acid) and RNA (Ribonucleic Acid) are both nucleic acids that play a crucial role in the storage and transfer of genetic information in living organisms. One of the major differences between DNA and RNA is the type of sugar molecule present in their structure. DNA is made up of deoxyribose sugar while RNA is made up of ribose sugar. Another major difference between DNA and RNA is their structure. DNA is a double-stranded helical structure while RNA is a single-stranded structure. The double-stranded structure of DNA allows for its stable storage of genetic information, while the single-stranded structure of RNA allows for flexibility in its function. Now, coming to the question, the options state that DNA and RNA differ in terms of the type of sugar molecule present in their structure and the nature of their structure. Option A suggests that DNA is made up of ribose sugar and is double-stranded unlike RNA, which is incorrect. Option B suggests that DNA is single-stranded unlike RNA, which is also incorrect. Option C suggests that RNA is double-stranded like DNA, which is incorrect. Option D is the correct option, which states that RNA is made up of ribose sugar and is single-stranded unlike DNA. Therefore, the correct answer is option D